Journal article
An investigation of the factors that regulate muscarinic receptor expression in schizophrenia
MS Seo, E Scarr, B Dean
Schizophrenia Research | ELSEVIER | Published : 2014
Abstract
We previously identified a group of subjects with schizophrenia who, on average, have a 75% decrease in cholinergic receptor, muscarinic 1 (CHRM1) in Brodmann's area (BA) 9. To extend this finding, we determined i) if the decrease in CHRM1 was present in another functionally related CNS region (BA6), ii) whether the marked decrease in CHRM1 was accompanied by changes in levels of other CHRMs and iii) potential factors responsible for the decreased CHRM1 expression. We measured CHRM1 and CHRM3 using in situ radioligand binding with [3H]pirenzepine and [3H]4-DAMP respectively in BA6 from 20 subjects with schizophrenia who had low levels of CHRM1 in BA9 (SzLow[3H]PZP), 18 subjects with schizoph..
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Grants
Awarded by MedStar Health Research Institute
Funding Acknowledgements
The authors gratefully acknowledge the assistance of Geoffrey Pavey for the preparation of post-mortem tissue for their roles in tissue collection and diagnostic confirmation. Tissues were received from the Victorian Brain Bank Network, supported by the Mental Health Research Institute, Alfred Hospital, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services and The Rebecca L. Cooper Medical Research Foundation. The study was supported by the Operational Infrastructure Support (OIS) from the Victorian State Government and NHMRC project grant 509306. Partial Funding for the Kodak 440CF was received from Perpetual Trustees. Brian Dean is a NHMRC Senior Research Fellow (400016). Elizabeth Scarr was a Royce Abbey Post-Doctoral Fellow and is an ARC Future Fellow (FT100100689). Myoung Suk Seo was supported by Melbourne International Fee Remission Scholarships and Melbourne International Research Scholarships.